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Other Products
Nattokinase Plus
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| Nattokinase |
100 mg , 1000 FU |
| Hesperidin |
100 mg |
| Pomegranate extract standardized to 40% ellagic acid |
100 mg |
| Niacinamide |
20 mg |
| Potassium (citrate/phosphate) |
33. 4 mg |
NATTOKINASE
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| Nattokinase is a powerful fibrinolytic enzyme, extracted from natto – a fermented product produced in Japan. Natto is made by fermenting soybeans with Bacillus natto. During this process nattokinase is produced by the Bacillus. Nattokinase is only found in natto – and not in other fermented soybean products.
Nattokinase was discovered in 1980 and shown to dissolve thrombi in vitro. Time taken to completely dissolve a thrombus was within 18 hours. Nattokinase resembles plasmin most closely (the natural enzyme produced by the human body to dissolve thrombi). Nattokinase acts by:
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Dissolving thrombi directly due to its plasmin-like activity |
| 2) |
Increasing the body?s production of plasmin and other thrombolytic enzymes such as urokinase. |
Nattokinase may be superior to conventional thrombolytic drugs (such as urokinase), since these are only effective when given intravenously. Unlike anti-thrombin drugs, which become ineffective after cessation of IV treatment, nattokinase also prevents blood coagulation and breaks down existing thrombi. By measuring the breakdown products of thrombi fibrin degradation products and euglobulin fibrinolytic activity, it has been demonstrated that nattokinase activity lasts from 8 to 12 hours. In addition, when nattokinase is given orally, there is a rise in blood TPA (tissue plasminogen activator), which shows that TPA is being released from endothelial cells and/or the liver. This is further evidence of the fibrinolytic activity of nattokinase.
Nattokinase can prevent arteriosclerosis with doses as small as 100 mg per day(1, 2)
THROMBOLYTIC ACTIVITY
Thrombolytic enzymes are normally generated in the endothelial cells of the blood vessels. As the body ages, production of these enzymes begins to decline, making blood more prone to coagulation. This can lead to cardiac or cerebral infarction, as well as other conditions. Since endothelial cells exist throughout the body, such as in the arteries, veins and lymphatic system, poor production of thrombolytic enzymes can lead to the development of thrombotic conditions virtually anywhere in the body.(2)
In Japan, it has been estimated that sixty percent of senile dementia is caused by reduced cerebral blood flow from thrombi. Other thrombotic diseases include cerebral hemorrhage, cerebral infarction, cardiac infarction and angina pectoris. Nattokinase is capable of directly breaking down fibrin in thrombi as well as activating pro-urokinase (endogenous) without side effects.(1, 2)
Animal and Human Studies
A single intraperitoneal injection of 25 mg of natto extract into male hypertensive Wistar rats decreased systolic pressure from 166 mmHg to 145 mmHg in two hours, with a further decrease to 144 mmHg in 3 hours.
In a small group of hypertensive human subjects, 30 g of lyophilized extract was administered orally for 4 consecutive days. In 4/5 subjects, the systolic BP decreased from an average of 173.8 +/- 20.5 mgHg to 154.8 +/- 12.6 mmHg. Diastolic BP decreased from 101.0 +/- 11.4 mmHg to 91.2 +/- 6.6 mmHg. On average, this data represents a 10.9 percent drop in systolic BP and a 9.7 percent drop in diastolic BP.(1,3)
Dogs which received nattokinase, had dissolution of the thrombus within 5 hours, whilst with the placebo dogs, there was no indication of dissolving the clot 18 hours after treatment. (1,3)
Other research showed that animals treated with nattokinase regained 62 percent of blood flow, whereas those treated with plasmin regained just 15.8 percent of blood flow.(1)
In 12 healthy Japanese volunteers, (6 men and 6 women), natto (200g) was administered orally. On average the ELT of these volunteers fell by 48% within 2 hours and this enhanced thrombolytic ability was retained for 2 to 8 hours.(1,3)
NATTOKINASE AND BLOOD PRESSURE
Nattokinase inhibits angiotensin converting enzyme (ACE), which converts angiotensin I to angiotensin II. ACE causes blood vessels to narrow and blood pressure to rise - by inhibiting ACE, nattokinase has a lowering effect on blood pressure.(1,4)
SUPPRESSION OF INTIMA THICKENING
Dietary natto extract supplementation was started 3 weeks before endothelial injury and continued for another 3 weeks after. In ex vivo studies, euglobulin clot lysis times were measured 3 weeks after the initial supplementation. Neointima formation and thickening were also initiated successfully. The intima media ratio 3 weeks after endothelial injury was 0.15 +/- 0.03 in the control group. Dietary natto extract supplementation suppressed intimal thickening (0.06 +/- 0.01; P < 0.05) compared with the control group. Natto extracts shortened euglobulin clot lysis time, suggesting that their thrombolytic activities were enhanced. These findings suggest that natto extracts, because of their thrombolytic activity, suppress intimal thickening after vascular injury as a result of the inhibition of mural thrombi formation(4)
HESPERIDIN
Hesperidin is the major bioflavonoid of oranges and lemons. It is flavanone glycoside (glucoside) comprised of the flavanone hesperitin and the disaccharide rutinose. Hesperidin has been shown to have an anti-hypertensive effect on hypertensive animals(5). In addition hesperidin has been shown to increase HDL levels and inhibit hypertrophy in vasculature(6).
1.Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly Blood Clots in Hours, Health Sciences Institute, March 2002
2.Maruyama M, Sumi H, Effect of Natto Diet on Blood Pressure, JTTAS, 1995
3.Sumi H, Hamada H, Nakanishi K,, Hiratani H, Enhancement of the Fibrinolytic Activity in plasma by oral administration of nattokinase, Acta Haematol, 1990, 84: 139-43
4.Suzuki Y, Kondo K, Matsumoto Y, Zhao BQ, Otsuguro K, Maeda T, Tsukamoto Y, Urano T, Umemura K, Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rate femoral artery, LifeSci 2003 73: 1289-98
5.Effects of long-term administration of hesperidin and glucosyl hesperidin to spontaneously hypertensive rats.J Nutr Sci Vitaminol (Tokyo). 2002 Oct;48:420-2.
6.Ohtsuki K, Abe A, Mistuzumi H, Kondo M, Uemura K, Iwasaki Y, Kondo Y, Glucosyl hesperidin improves serum cholesterol composition and inhibits hypertrophy in vasculature, J Nutr Sci Vitaminol (Tokyo), 2003, 49: 447-50
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